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中文
这个转基因构建包含一个突变的人类MAPT（tauKQ）基因，通过替换为谷氨酰胺的lysine氨基酸，模拟了在鼠Prnp基因启动子控制下MAPT的K274和K281的乙酰化。这两个核苷酸变化分别是820位的A替换成C，以及841位的A替换为C。Founder line 286相较于Founder line 1，其转基因的表达量更高。这个基因在海马、皮质和小脑中都有表达。（来源：J:230252）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
