在exon 3'的上游插入了loxP位点,接着是含氨苄青霉素抗性基因座的FRT序列,再在exon 3'的下游也插入了loxP位点。随后通过flp介导的重组,去除了neo cassette,得到了一个条件性可操作的等位基因,其exon 3'编码的deltaN亚型被-loxP标记。(来源:J:218385)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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