使用Gt(ROSA)26Sortm2Bgh的重组,将hygromycin抗性元件替换为四环素响应元件,驱动tdTomato报告基因的诱导表达,包括2A肽序列和带有四处稳定突变的murine Ctnnb1 cDNA(包括S33A、S37A、T41A和S45A),后面跟着polyadenylation序列。(来源:J:222531)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count