使用Gt(ROSA)26Sortm2Bgh的重组,将hygromycin抗性元件替换为四环素响应元件,驱动tdTomato报告基因的诱导表达,包括2A肽序列和带有四处稳定突变的murine Ctnnb1 cDNA(包括S33A、S37A、T41A和S45A),后面跟着polyadenylation序列。(来源:J:222531)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
插入
--
--
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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