A construct containing the tetracycline responsive element, comprising seven tandem copies of the 19-base pair tetracycline operator (tetO), followed by cDNA encoding vascular endothelial growth factor C was introduced by FLP recombinase-mediated cassette exchange (RCME) into the frt docking site of Col1a1tm13(neo/hygro*)Jae in KH2 ES cells. (J:82809)