在内皮3通过同源重组插入了一个由neomycin-stop cassette和loxP座点环绕的元件。通过Cre介导的重组可以恢复基因表达。对携带母源性突变的 mice 大脑(海马、皮质和小脑)进行 Western blot 分析显示,蛋白质水平显著降低。(来源:J:222400)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
6
8

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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