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中文
设计了一个靶向载体，用于在第9外显子插入GGA到CGA的突变，产生G418位点的甘氨酸替换为精氨酸（G418R），并包含一个克隆敲除的诺卡因抗性基因。通过Cre介导的重组，去除了这个克隆的诺卡因抗性。小鼠的G418R突变类似于人类酒窝婴儿中常见的G420R变异。（来源：J:221901）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
