Tg(SOD1*H46R*C111S)PAra

A 12 kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the cysteine residue at position 111 was replaced by serine. Five lines were established, including lines N, P, and Q. This line has 24-36 copy numbers of the transgene. (J:221350)