在B6(Cg)-Tyrc-2J>/J衍生的ES细胞中,将外源的Exon 12(编码锌指域),以及Intron 11的55bp内序列和3'UTR的106bp下游序列插入,替换了原有的基因序列。同时,一个FRT引导的诺卡因选择标记被插入在Exon 12的末端后621bp的位置。(参考文献:J:222816, J:226896)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6(Cg)-Tyrc-2J/J
Targeted
Insertion, Other
不确定
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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