将第一个编码外显子替换为一种可诱导的Cre重组酶基因(cre/ERT2),其带有三个串联的血红蛋白(HA)标签。Cre介导的重组移除了含荧光素酶耐药基因座。P30时的免疫组化结果显示视网膜中未检测到蛋白表达。(来源:J:225578)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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