这个靶向构建是为了在基因的第1外显子下游插入一个由loxP序列标记的诺卡因抗性元件。3' UTR区域的突变(AGCTTAA替换为AGCAAATT)对应于miR-155(微小RNA155)可能的靶标位点,产生了无义突变。随后,Cre介导的重组去除了含有的floxed neo cassette。(来源:J:226678)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6(Cg)-Tyrc-2J
Targeted
Insertion, Nucleotide substitutions
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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