靶向载体设计为在exon 2上游有loxP位点,随后是FRT框引导的neo cassette,后面跟着一个在exon 4下游的loxP位点。通过Flp介导的重组移除了FRT框引导的neo cassette,使得exons 2到4成为可剪接的区域。(来源:J:229516)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count