靶向载体设计为在exon 2上游有loxP位点,随后是FRT框引导的neo cassette,后面跟着一个在exon 4下游的loxP位点。通过Flp介导的重组移除了FRT框引导的neo cassette,使得exons 2到4成为可剪接的区域。(来源:J:229516)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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