The Multiple Species Conserved Sequence 4 (MCS 4) distal enhancer with a c-Fos minimal promoter drives neural crest cell and derivatives-specific expression of an inducible cre recombinase gene flanked by two modified estrogen receptors (ERT2/cre/ERT2) followed by a rabbit globin polyadenylation sequence. Two lines were generated with line 17 selected as the representative line. (J:226186)