一段由Camk2 1.3 alpha启动子控制的人类120个氨基酸的截短的α-synuclein cDNA被生成,形成了三条转基因小鼠线(1、2和3)。这些小鼠与C57BL/6JOlaHsd小鼠杂交,后者由于α-SNCA基因座的自发缺失,不产生α-synuclein(来源:J:219640)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x CBA/J)F1/J
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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