设计了一种靶向载体,它包含在exon 22上游的loxP位点、exon 22下游的第二个loxP位点,以及一个由FRT引导的诺卡因抗性(neo)基因座,后者包含第三个loxP位点。通过FLP介导的重组,FRT引导的neo基因座被移除,exon 22区域被标记为可删除的。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Targeted
插入
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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