通过Cre介导的父本Hbb-bh2tm1a(EUCOMM)Hmgu基因座切除,去除了驱动诺卡因选择标记的启动子元件和关键外显子,保留了插入的lacZ报告基因序列。欲了解针对此类IKMC等基因座的靶向策略详情,请访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count