通过Cre介导的父本Slc4a10tm1a(KOMP)Wtsi基因座切除,去除了驱动新霉素筛选 cassette 的启动子,并保留了插入的lacZ报告序列,可能还去除了关键的内含子。欲了解针对此类IKMC等基因座的靶向策略详情,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count