通过Flp介导的父本Mthfd2ltm1a(EUCOMM)Wtsi基因座的去除,删除了由启动子驱动的诺卡因选择标记片段和插入的lacZ报告序列,保留了loxP引导的至关重要外显子。欲了解针对此IKMC等其他基因座的靶向策略详情,请访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count