通过Cre介导的父本Ch25htm1(KOMP)Vlcg基因座的去除,去除了新霉素选择标记基因座,以及关键的外显子,留下插入的lacZ报告序列。有关这种IKMC等其他基因座靶向策略的更多细节,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:204739)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count