将鸡β-actin(CAG)启动子、一个由loxP序列标记的停止子元件,以及带有外源性W290C突变的人类FGFR2编码区域插入小鼠胶原A1基因座。通过Cre介导的重组,这个停止子元件会被剔除,从而驱动突变型FGFR2的表达。(来源:J:214230)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入
--
1
24
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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