将鸡β-actin(CAG)启动子、一个由loxP序列标记的停止子元件,以及带有外源性W290C突变的人类FGFR2编码区域插入小鼠胶原A1基因座。通过Cre介导的重组,这个停止子元件会被剔除,从而驱动突变型FGFR2的表达。(来源:J:214230)
Basic Information
(C57BL/6 x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count