一个包含整个开放阅读框(2-6号外显子)的基因区域被替换为一个构建,该构建包含NLS-lacZ、病毒T2A序列、histone 2B、Venus报告基因和SV40-pA,以及一个通过同源重组固定的neo cassette。随后,通过Cre介导的重组移除了neo cassette(来源:J:215971)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6J x 129S6/SvEvTac)F1
Targeted
插入,基因内删除
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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