Exon 15被通过同源重组插入了内含子和IRE斯,lacZ和neo cassette,这导致在中枢和周围神经系统神经元中的表达中断。 Western blot和免疫荧光分析证实了这一表达的阻断。(来源:J:214739)
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Exon 15 was disrupted by insertion of and IRES, lacZ, neo cassette via homologous recombination. Western blot and immunofluorescence analysis confirmed disruption of expression in neurons of the central and peripheral nervous system. (J:214739)