Mdes4kb-lacZ transgenic construct bears a 4.6 kb EcoRI/SalI desmin promoter (from -4005 to +608) and a lacZ reporter gene with a nuclear localization signal. This 4 kb upstream region of the murine desmin promoter directs expression of the LacZ reporter gene throughout the heart from E7.5 and in skeletal muscle and vascular smooth muscle cells from E9.5. Line numbers were not specified. (J:65247)