Wrn^b2b3121.1Clo

This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b3121Clo. The molecular lesion is a G to A substitution at coding nucleotide position 3502 in exon 28 of the cDNA (c.3502G>A, NM_001122822). This changes the glycine residue to serine at position 1168 of the encoded protein (p.G1168S). (J:175213)