A human SP-C delta exon4 cDNA was generated by deleting nucleotides 325435 (adenosine of start ATG is base pair 1). A transgene construct was generated by subcloning the human SP-C delta exon4 cDNA into a vector containing the 13-kb mouse SP-C promoter, a rabbit globin intronic/exonic sequences, and a bovine growth hormone polyadenylation signal. Two founder mice were generated but did not survive. (J:87084)