将编码人类KCNIP3(DREAM)的cDNA,其中在EFhand2、3和4位点各插入了两个氨基酸替换(EFmDREAM),插入在人类CaMKII启动子下游。cDNA后面跟着一个IRES和lacZ报告基因。这些氨基酸改变使得突变体对钙离子失去敏感性,从而能阻止DREAM和内源性表达的其他KChIP蛋白的钙离子依赖性去激活功能。(来源:J:103733)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 CBA)F1
--
插入
--
1
--
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部