Exon 2缺失了,由Cre重组酶造成了,留下一个loxP位点。在5' loxP位点下游的、来自Intron 1的内含子1中,有一个被删除的含诺卡因抗性基因簇(frt-flanked neomycin resistance cassette)。 Western blot结果显示,同源纯合突变小鼠的胸腺、脾和睾丸中没有编码蛋白。(来源:J:220670)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入,基因内删除
不确定
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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