带有F3、Frt、LoxP和Lox511介导条件锁定区域的基因陷阱元件,插入到了β-geo报告基因的1号外显子中,随后通过Flp剔除系的杂交,产生了这种突变型,插入位点在负链上呈反向排列,转录功能正常,但依旧受Cre介导的反转作用影响。(来源:J:236978)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
基因捕获载体的插入
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1
6
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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