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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
转基因模型
Tg(Cx3cl1*)1Jung
Alias:
CX3CL1
105delta
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基础信息
表型特征
文献报道
使用了BAC(细菌人工染色体)文库(CHORI)来获得一个包含整套小鼠Cx3cl1(chemokine(CTX3-C motif)ligand 1)基因的120kb BAC,编号为#RP24147I16。这个BAC经过改造,插入了一个在第105位的终止密码子,并在第3外显子后面接上了myc标签。通过限制性酶切,BAC中去除了CCL22和CCL17的序列。转基因编码的是一种分泌的、无黏液基质部分的截短蛋白。参考文献为(J:178874)。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
5644036
(BALB/c x C57BL/6)F1
--
Insertion, Nucleotide substitutions
--
1
--
2
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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