设计了一种靶向载体,它在胶原蛋白A1(Col1a1)启动子下游插入了从5'到3'的CAG启动子、含Frt-CreERT2(一种Cre重组酶连接到雌激素受体配体结合域)编码序列的区域,以及attB/attP介导的诺卡因抗性基因 cassette(neo)。通过ΦC31介导的重组,去除了neo cassette。(来源:J:101977)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
插入
--
1
24
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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