这个转基因表达的是小鼠的Rho蛋白,其中的Thr336、Thr340和Thr342被替换成了无活性的Ala,而与之相关的丝氨酸磷酸化位点(Ser334、Ser338和Ser343)保持功能。引入了A337V突变,以引入一个线性表位,用于抗体mAb3A6的特异识别,区分转基因蛋白和内源性视素(J:221472)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F1
--
Insertion, Nucleotide substitutions
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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