这个转基因表达的是带有S334、T336、S338、T340和T342磷酸化位点的鼠Rho蛋白。Rho转基因中剩下的S343磷酸化位点通过苏氨酸到 Alanine 的突变被去活。引入了A337V变异,以提供线性表位,以便mAb3A6特异性识别转基因Rho与内源性视素的区别。(来源:J:188325)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x DBA/2J)F1
--
Insertion, Nucleotide substitutions
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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