Exon 2被标记并插入了通过同源重组的floxed neo cassette。通过Cre介导的重组,去除了Exon 2和neo cassette。分子分析确认了野生型和纯合突变小鼠胚胎成纤维细胞(MEFs)以及睾丸提取物中相应mRNA和蛋白的缺失(来源:J:213588)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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