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中文
一个包括2-11号外显子的基因区域通过同源重组被NLS-lacZ载体和FRT引导的neo cassette替换。通过Flp介导的重组移除了neo cassette。在实验中，检测到在异种小鼠（homozygous mutant mice）的表皮和真皮中， ceramide synthase活性显著下降，对C20酰-CoA的转化大约减少了10%和20%。（来源：J:213606）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
