一个敲除的诺卡因抗性基因座取代了大部分exon 4。在exon 4的剩余部分下游,额外插入了一个框内终止密码子。这个缺失导致了锌指结构ZF2到ZF30的丢失,其中ZF9到ZF30的区域对于神经诱导活动是必需的。北向杂交分析证实了大脑中转录表达的存在缺失。(来源:J:214267)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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