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中文
为了产生这种突变等位基因，设计了一种ACN靶向载体，通过定点突变，将第1278位的arginine替换为proline(即p.R1278P)。ACN载体包含由精子特异性血管紧张素转换酶启动子驱动的neomycin抗性基因和cre重组酶基因，周围有loxP位点。在杂合雄性生殖细胞中，cre介导的重组会移除载体，留下一个位于第27号内含子的loxP位点。这种突变等同于人类的p.R1276P变异。(来源：J:94077)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
