Slc33a1^tm1.1Lpu

A serine to arginine substitution was introduced at amino acid 113 and a floxed pgk-neo cassette was inserted via homologous recombination. Cre mediated recombination removed the neo cassette. The mutation impairs the ability of the protein to form homodimers in the ER membrane. The resulting protein is devoid of acetyl-CoA transport activity. (J:211266)