设计了一种靶向载体,包含一个loxP序列,后面跟着FRT引导的诺卡因抗性(neo)基因座,位于exon 2上游,然后是exon 2下游的另一个loxP位点。通过Flp介导的重组,FRT引导的neo基因座被移除,exon 2区域被标记为可靶向敲除。(来源:J:261348)
Basic Information
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count