RMCE(通过Kcnq2tm1Snhr引入)使用了修改过的第六外显子,其中G变A的点突变导致了第306位氨基酸由丝氨酸替换为天冬氨酸(A306T)。通过Flp介导的重组去除了新霉素选择标记基因元件。(来源:J:213443)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
Insertion, Single point
--
1
14
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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