Crx^tm2.1Smgc

Exon 4 was modified by nucleotide substitutions (CGT to TGG) that result in the amino acid substitution of tryptophan for arginine at position 90 (R90W) in the DNA binding domain, mimicking a mutation associated with the autosomal dominant form of cone-rod dystrophy (adCoRD) and with autosomal recessive Leber Congenital Amaurosis (LCA). Cre-mediated recombination removed the floxed allele inserted upstream of exon 4. (J:211011)