通过Flp介导的父本Hiratm1a(EUCOMM)Wtsi基因座的切除,去除了诺卡因选择标记序列和插入的lacZ报告基因,剩下的是带有loxP序列的關鍵外显子4。欲了解针对此类IKMC等基因座的靶向策略详情,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:173534, J:212533)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count