这个靶向载体包含在exon 1外侧的loxP位点,包括起始密码子。下游位置插入了FRT标记的诺卡因抗性(neo)基因座,连接着内源性启动子(IRES)和一个splice捐赠子(SD)序列,再跟着第三个loxP位点。通过Flp介导的重组,FRT标记的neo-IRES-SD元件被移除。(来源:J:213820)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
--
11

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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