在exon 2的上游(位置10310)插入了loxP位点,然后通过同源重组在exon 4下游(位置12190)插入了带有FRT框的neo cassette和另一个loxP位点。通过Flp介导的重组,neo cassette被移除了。对C57BL/6J小鼠Cd1d2基因的自发突变进行PCR确认了在C57BL/6J等位基因中的整合。(来源:J:210436)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6J)F1
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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