克隆7B8来源于对TH17小肠CD4+T细胞进行筛选,这些细胞对SFB单特异性关联小鼠的粪便物质有反应。该受体能识别SFB的表位FSGAVPNK。克隆所关联的CDR3Vbeta14序列(AWSRSPSQNTLY)和Valpha15序列(AEGNMGYKLT)被插入到能由天然TCRalpha和-beta启动子/增强子驱动转录的载体中。(来源:J:212833)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count