编码Toll-IL-1受体(TIR)区域的3-5外显子周围有loxP位点,接着是frt引导的诺卡因抗性元件,通过flp介导的重组被去除。当cre介导的重组去除可翻转序列时,从exon 2到exon 6的剪接会引发框架突变。(来源:J:209373)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
B6.Cg-Thy1a
Targeted
插入
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1
4
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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