L1L2_gt1 cassette被插入到染色体14的56,792,283位置,位于关键外显子(Build GRCm39)上游。这个 cassette 包含FRT引导的lacZ/新霉素序列,后面跟着一个loxP位点。在目标外显子(s)下游,再插入了一个loxP位点,位置是56,793,168。因此,关键外显子(s)被loxP位点包围。Cre和Flp介导的重组产生了敲除等位基因。更多关于这种IKMC等位基因的靶向策略信息,可访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(J:173534)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N
Targeted
插入,基因内删除
--
1
8
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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