在ATG起始密码子处插入了带有SV40核定位信号的LacZ和反向排列的PGK-Neo基因,然后替换掉了exon 1。PCR结果显示没有转录本。成人的视网膜、前列腺、皮肤、膀胱、睾丸、肺和脑中都观察到了阳性核性β-gal表达。(来源:J:216357)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入,基因内删除
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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