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中文
Exon 2被替换为包含人类ABCC2从2号到32号所有外显子的cDNA，带有polyA信号和一个neo cassette，通过同源重组插入。通过Flp介导的重组移除了neo cassette。定量PCR结果显示，纯合小鼠基因不表达，而人类基因在肝脏、肾脏和肠道中稳定表达，且人类基因的表达水平高于小鼠基因。 Western blot分析确认了肝脏、肾脏和肠道中纯合小鼠蛋白的缺失，而人类蛋白得到了表达。(来源：J:216646)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
