磁带由5'至3'方向包含一个FRT启动子,一个含有β-半乳糖苷酶序列的En2剪接接受器磁带,以及下游插入了loxP标记的诺卡因抗性基因磁带,该磁带也包含一个FRT启动子。在exon 1之后,再插入了第三个loxP位点。关键外显子被loxP位点所夹峙。通过FLP介导的重组,去除了带有FRT标记的lacZ和neo基因磁带,留下exon 2由loxP位点 flank。欲了解针对此类IKMC等位基因的靶向策略详情,请参阅http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:155845, J:213699)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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