这个来自Fastkd5-6053J-P4MB项目的等位基因是在Jackson实验室通过向细胞注射Cas9 RNA和引导序列GTGGTATGCCGAAGATTTAC产生的,导致了2号染色体负链130,616,640bp位置起始的14bp缺失,序列变为TGCCGAAGATTTAC。这个变异预测会导致第5位氨基酸之后的序列改变以及随后的21个早期终止密码子。(J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
基因内删除
不确定
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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