在exon 1的上游插入了34bp的loxP序列,随后在 intron 1内插入了一个6.4kb的PGK-neo-HsvTK基因座,它被两个loxP位点 flank。通过Cre介导的重组,去除了loxP标记的选择性 cassette和exon 1。逆转录-qPCR证实了杂合雌性的mRNA表达水平降低。(来源:J:208796)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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